Table 4 Human leukocyte antigen associations in primary biliary cirrhosis.

Allele	Nature of association	Reproducible	Population group	Frequency range in PBC
DRB1*0801†	Susceptibility	Yes	Northern & southern European, USA Caucasian, Canadian86,87,88,89,90	12–18%
DRB1*0803	Susceptibility	Yes	Japanese91,92,93	30–35%
DQA1*0401†	Susceptibility	Yes	Northern & southern European, USA Caucasian87,88,89,90	14–18%
DQB1*0402†	Susceptibility	Yes	Northern & southern European, USA Caucasian86,87,88,89	11–21%
DRB1*0701	Susceptibility	No	Chinese94	29%
DRB1*13	Protection	Yes	Northern & southern European87	10–14%
DRB1*1101	Protection	Yes	Southern European & USA87,95,96	7–28%
DPB1*0301	Susceptibility	No	Northern European97	50%
DPB1*0501	Susceptibility	No	Japanese98	85%

PBC, primary biliary cirrhosis.

^†Alleles within disease associated‐haplotypes.