Table 1.

Histological scores for AIA in IL-6-deficient and wild-type mice

Group	Genotype	Mice per group	Histology score of mice at day 35
			0	1	2	3	4	Mean ± SE
I	IL-6 +/+	10	—	—	—	2	8	3.8 ± 0.18
II	IL-6 −/−	10	—	2	8	—	—	1.8 ± 0.18*

Both groups were immunized in the standard manner and sacrificed 35 days after the first immunization. The histopathologies of the knee joints were scored from 0 to 4 as described in Materials and Methods. ∗, P < 0.001, IL-6 −/− compared to IL-6 +/+.