Figure 2 Modulation of IFN‐γ production by mucosal T‐cell clones. Effect of IL12 and IL4 on IFN‐γ production by mucosal T‐cell clones from children with normal mucosa (19 clones from three patients; 5, 9 and 10, respectively), a child with Campylobacter colitis (10 clones from one patient), and children with early (39 clones from five patients; 8, 12, 7, 6, and 6, respectively) and late (21 clones from three patients; 10, 6, and 5, respectively) Crohn's disease. Clones were separately derived from mucosal biopsies in the presence of IL2, IL2 plus IL12, and IL2 plus IL4 from the beginning of the culture, stimulated by anti‐CD3 antibody plus phorbol ester for 48 hours to obtain supernatants for IFN‐γ measurement. Data are expressed as mean ± SE. For Campylobacter colitis the displayed SE are within patient. *p = 0.0004, **p = 0.0001, and ***p = 0.0001, compared with IL2 alone in Campylobacter colitis, and early Crohn's disease, respectively.