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. 2007 Sep 18;35(19):6399–6413. doi: 10.1093/nar/gkm680

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© 2007 The Author(s)

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/2.0/uk/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 4. — Control of aberrant splice-site activation by predicted SF2/ASF ESE motifs. (A) A rainbow gradient of SF2/ASF-mediated exon/intron definition. The SF2/ASF ESE score density (IgM-BRCA1 version) was calculated as a sum of SF2/ASF ESE scores in each sequence group, divided by the sequence length and multiplied by 100. Each category is denoted by a colour shown on the right. Sequence categories were ordered from the highest score density to the lowest. For HM-EX and ALT-EX, only 1000 randomly selected sequences were analysed due to size limitations of the server. (B) The SR ESE motif densities in aberrant 5′ss. Each SR protein is represented by a colour shown on the right side.