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Thermodynamic stabilities of homo-DNA and p-RNA duplexes with antiparallel and parallel orientation of strands. UV-melting curves for 1:1 mixtures of (A) homo-DNA and (B) p-RNA 16-mers with opposite (top) and equal (bottom) strand polarities. The apparent melting profiles of the duplexes with ps-orientation of strands are due to the temperature-dependent hyperchromicities of the constituting single strands (data not shown).
