Figure 1.

LVDP prior to 45 min of global ischemia and during reperfusion in four groups of perfused guinea pig hearts (n = 9 for each group): 1, following 8 wk 15% ethanol-derived calories (○); 2, pair-fed controls (▵); 3, following 8 wk of ethanol, before and after 10 mM chelerythrine (•); and 4, pair-fed controls, before and after chelerythrine (▪). LVDP recovery is significantly greater in hearts from ethanol-treated animals (P < 0.05 at each 6-min interval). Chelerythrine abolished ethanol’s protective effect on LVDP recovery. Data are presented as mean ± SEM (SEM not included for group 2 but lie well within SEM of groups 3 and 4).