Table 4.
Genotype frequencies and risk of prostate cancer in non-, light-, and heavy-smoking categories.
| UGT2B17 genotypea | Cases (%) | Controls (%) | OR (95% CI)b |
|---|---|---|---|
| Non-smokers | |||
| (+/+) | 61 (53) | 76 (48) | 1.00 (Ref.) |
| (+/0) | 44 (38) | 63 (39) | 0.84 (0.49–1.44) |
| (0/0) | 10 (9) | 21 (13) | 0.62 (0.26–1.49) |
| (+/+) | 61 (53) | 76 (48) | 1.00 (Ref.) |
| (+/0) + (0/0) | 54 (47) | 84 (52) | 0.79 (0.47–1.31) |
| (+/+) + (+/0) | 105 (91) | 139 (87) | 1.00 (Ref.) |
| (0/0) | 10 (9) | 21 (13) | 0.67 (0.29–1.56) |
| Light-smokersc | |||
| (+/+) | 65 (49) | 61 (50) | 1.00 (Ref.) |
| (+/0) | 50 (37) | 42 (35) | 1.25 (0.70–2.21) |
| (0/0) | 19 (14) | 18 (15) | 1.10 (0.49–2.46) |
| (+/+) | 65 (49) | 61 (50) | 1.00 (Ref.) |
| (+/0) + (0/0) | 69 (51) | 60 (50) | 1.20 (0.71–2.04) |
| (+/+) + (+/0) | 115 (86) | 103 (85) | 1.00 (Ref.) |
| (0/0) | 19 (14) | 18 (15) | 1.00 (0.46–2.16) |
| Heavy-smokersc | |||
| (+/+) | 75 (46) | 53 (46) | 1.00 (Ref.) |
| (+/0) | 74 (46) | 54 (46) | 0.94 (0.57–1.56) |
| (0/0) | 13 (8) | 9 (8) | 0.97 (0.38–2.47) |
| (+/+) | 75 (46) | 53 (46) | 1.00 (Ref.) |
| (+/0) + (0/0) | 87 (54) | 63 (54) | 0.95 (0.58–1.54) |
| (+/+) + (+/0) | 149 (92) | 107 (92) | 1.00 (Ref.) |
| (0/0) | 13 (8) | 9 (8) | 1.00 (0.40–2.45) |
a
The three genotypes of the UGT2B17 deletion polymorphism are shown as: (+/+), two alleles of the UGT2B17 gene; (+/0), one allele of the UGT2B17 gene and one gene deletion allele; (0/0), UGT2B17 null, two copies of the deletion allele.
b
Adjusted for age, smoking pack-years (except non-smokers), and family history of prostate cancer.
c
Light- versus heavy-smoker categories, subjects stratified at the median for all smokers in the study population.