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. 2007 Dec 3;117(12):3868–3878. doi: 10.1172/JCI33559

Figure 4. α-OX40L mAb inhibits OVA-induced inflammation in the lung mediated by activation of memory T cells.

Figure 4

(A) Experimental design for OVA-induced lung inflammation is shown. BALB/c mice (n = 5 per group) were sensitized with OVA/alum (or control alum alone) on day 0. To assay effects of α-OX40L mAb treatment on primary effector responses, mice were challenged with OVA intranasally on days 7, 8, 9, and 10 and analyzed for BALF inflammation on day 11. For memory responses, mice were challenged on days 25, 26, 27, and 28 and analyzed on day 29. Mice were treated with 150 μg control mIgG2a and α-OX40L 4F5 mAbs intraperitoneally on days 7 and 9 for primary responses, and days 25 and 27 for memory responses. (B) Numbers of infiltrating lymphocytes, eosinophils, and activated CD4+ T cells per ml of BALF on days 11 and 29 are shown. (C) Levels of IL-4, IL-5, and IL-13 in the BALF on days 11 and 29 are shown. (D) Levels of antigen-specific serum IgE are shown. Results are the mean ± SD. *P < 0.01 (Dunnett’s test).