Figure 1.
Schematic representation of the human cyclin D1 promoter. The pXP2-CD1 reporter vector contains the cyclin D1 regulatory region here shown. TRE(AP-1), TRE, −924 to −938 (Herber et al., 1994); dE2F, distal E2F, −730 to −737 (Herber et al., 1994); E box, bHLH, and Zn finger transcription factors binding site, −547 to −553 (Herber et al., 1994); ZONAB, ZONAB binding site and inverted CCAAT box, −527 to −532 (Sourisseau et al., 2006); Oct, Oct binding site, −646 to −652 (Cicatiello et al., 2004); pE2F, proximal E2F, −133 to −143 (Watanabe et al., 1998); Tcf/Lef, Tcf/Lef binding site, −67 to −77 (Shtutman et al., 1999); CRE, −46 to −53, (Herber et al., 1994); and Start, site of transcription initiation, −1/+1 (Herber et al., 1994). Broken arrow stands for the transcription start point.