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The oxypurine cycle. The enzymes participating in the cycle are: 1 HPRT; 2 cN-II; 3 purine nucleoside phosphorylase (PNP). The net reaction is the hydrolysis of 5-PRPP to Rib 1-P and inorganic pyrophosphate (PPi). The allosteric activation by ATP and 2-3-BPG, and the inhibition by Pi, modulate the cycle rate. Modified from Leach et al., 1998 [33]
