Table 2.
Summary of extracellular nucleotide regulation of iNOS expression and NO production by immune cells
| LPS-stimulated event and system studied | Nucleotide and effect* | References |
|---|---|---|
| Nitric oxide (NO) production | ||
| LPS+ IFNγ-treated murine (CD-1) peritoneal macrophages | 2-MeS-ATP: ↑ | [83] |
| LPS-treated RAW 264.7 murine macrophages | oATP: ↑ | [65, 87] |
| LPS-treated RAW 264.7 murine macrophages | ADP: ↑ | [85] |
| LPS-treated RAW 264.7 murine macrophages | ATP: ↑ | [86] |
| LPS-treated RAW 264.7 murine macrophages | ATP or BzATP: ↑ | [66] |
| LPS-treated rat astrocytes | ATP, ADP, AMP, UTP, BzATP, or 2-MeS-ATP: ↑ | [88] |
| oATP: ↑ | ||
| IFNγ-treated BV-2 murine microglia cells | ATP, ADP, BzATP, or 2-MeS-ATP: ↑ | [89] |
| IL-1β/IFNγ-treated human astrocytes | BzATP: ↑ | [90] |
| iNOS expression | ||
| LPS-treated RAW 264.7 murine macrophages | ATP: ↑ | [84] |
| LPS+ IFNγ-treated murine (CD-1) peritoneal macrophages | 2-MeS-ATP: ↑ | [83] |
| LPS-treated RAW 264.7 murine macrophages | PPADS: ↑oATP: ↑ | [87] |
| LPS-treated RAW 264.7 murine macrophages | BzATP: ↑ | [65, 66] |
| LPS-treated RAW 264.7 murine macrophages | ATP: ↑ | [88] |
| IFNγ-treated murine BV-2 microglia cells | BzATP or ATP: ↑ | [89] |
* The upward arrow (↑ indicates that the specified nucleotide enhanced the indicated parameter (NO production or iNOS expression), whereas the downward arrow (↑ designates that the specified nucleotide or inhibitor attenuated the indicated parameter.