Table 2.
Correlation between pathologic and immunochemical findings
| Patient | Cerebral cortex
|
Cerebellum
|
||||
|---|---|---|---|---|---|---|
| Pathology (H&E) | PrP IHC (3F4) | Mr of PrP-res | Pathology (H&E) | PrP IHC (3F4) | Mr of PrP-res | |
| 1 | SP + PL | SYN + PL | NA | PL | PL | 21 (traces) and 8 |
| 2 | SP + PL | SYN + PL | 21 and 8 | SP + PL | SYN + PL | 21 and 8 |
| 3 | SP + PL | NA | 21 and 8 | SP + PL | NA | NA |
| 4 | SP + PL | NA | 21 and 8 | NA | NA | NA |
| 5 | SP + PL | SYN + PL | 21 and 8 | SP + PL | SYN + PL | 21 and 8 |
| 6 | PL (F) | PL (F), DPL | 8 | PL | PL | 8 |
| 7 | PL | NA | 8 | PL | NA | NA |
IHC, immunohistochemistry; H&F, hematoxylin and eosin; Mr, molecular weight; SP, spongiosis; PL, amyloid plaques (pathology) or plaque-like deposits (IHC); SYN, “synaptic” PrP deposition; NA, not available; DPL, diffuse plaque deposits (preamyloid); (F), Focal.