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Panel A: Mean group total distance traveled (cm) over a 45 min test period for rats infused icv with either 0, 3 or 30 nmol 5-methylurapidil and injected with vehicle (0 mg/kg cocaine). Panel B: Mean group total distance traveled (cm) for rats infused icv with 0 nmol 5-methylurapidil and injected with 0, 2.5, 5.0, 10 and 20 mg/kg cocaine. The vertical line above each symbol represents the SEM.
