Although the 5-HT2A/2C receptor antagonist ketanserin did not alter the frequency of either spontaneous or fictive inspiratory-related GABAergic IPSCs to CVNs, A, B, in the presence of ketanserin multiple applications of α-Me-5-HT evoked a significant decrease in the frequency of spontaneous (p < 0.05, n = 7) but not inspiratory-related (n = 7) GABAergic IPSCs to CVNs, C.