Figure 4.

(A) Macroscopic Kir6.2/SUR1 currents recorded in a giant inside-out patch in response to a series of voltage ramps from −110 to +100 mV from a holding potential of 0 mV. α-Endosulfine (2 μM) was added to the intracellular solution as indicated. (B) Effects of intracellular α-endosulfine concentration on the macroscopic Kir6.2/SUR1 conductance recorded from inside-out patches, expressed as a percentage of its amplitude (G/Gc) in control solution (without α-endosulfine). Data are expressed as means ± SEM, and the number of experiments is indicated above each column.