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. Author manuscript; available in PMC: 2008 Oct 31.
Published in final edited form as: Eur J Pharmacol. 2007 Jun 29;572(2-3):94–101. doi: 10.1016/j.ejphar.2007.06.028

Figure 2.

Figure 2

Effects of 17PA on alphaxalone-induced loss of righting reflex. a. I.c.v. administration of 17PA did not significantly alter sedative/hypnotic action of the synthetic neurosteroid, alphaxalone. Pre-treatment with 17PA (10 nmoles) did not produce a significant shift in the percentage of animals exhibiting loss of righting reflex to intravenous administration of alphaxalone (1.25 – 10.0 mg/kg). b. I.c.v. administration of 17PA does not significantly reduce alphaxalone-induced loss of righting reflex duration as revealed by a two-way repeated measures ANOVA (F = 0.58, df =1,104, P = 0.46).