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Modulation of IUS by lidocaine. The protocol was analogous to Fig. 2 A. After control oocytes were superfused with 300 μM lidocaine, which resulted in a significant acceleration of recovery from IUS. Data points were fitted with Eq. 5. Fitting parameters were drug free: A1 = 0.29 ± 0.07, τ1 = 9.8 ± 1.3 s, A2 = 0.71 ± 0.07, τ2 = 149.1 ± 6.8 s; lidocaine: A1 = 0.64 ± 0.04 (P < 0.05), τ1 = 10.0 ± 0.7 s, n.s., A2 = 0.35 ± 0.04 (P < 0.05), τ2 = 159.72 ± 16 s, n.s., n = 3).
