FIGURE 5.

(A) Effect of Ag⁺ on I_US in K1237C. Time course of peak inward sodium currents during a typical experiment. The experimental protocol was analogous to Fig. 2 C. Because of the irreversible modification of the channels by Ag⁺, the exposure to Ag⁺ (∼2 nM) was terminated after the current was reduced to by ∼30%. (B) Normalized time course of recovery from I_US. Peak inward currents from the experiment shown in A were normalized to the respective maximum after full recovery. Superfusion with ∼2 nM Ag⁺ did not substantially affect the time course of recovery from I_US.