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Increased MMP activity in diabetes. (A) Vessel segments were analyzed for morphological changes and collagen deposition by Masson staining which did not show any difference between control and diabetes groups. (B) A representative zymogram showing changes in vascular MMP-2 activity and densitometric analysis of lytic bands from all samples indicates an increase in MMP-2 activity. Results are given mean ± sem (n = 5–9) and *p < 0.05 vs control.
