TABLE 2.
Direct targets of PRDM5 as established by ChIP and deregulation following RNAi
| Primary gene function and gene name | Accession no.a |
|---|---|
| Signal transduction | |
| PIAS3 | NM_006099 |
| PPP1R12B | NM_032105 |
| MyD88 | NM_002468 |
| IL6R | NM_000565 |
| MyD118 | NM_015675 |
| GPR1 | NM_005279 |
| EDNRA | NM_001957 |
| NCOA7 | NM_181782 |
| WNT10B | NM_003394 |
| CKLF | NM_181641 |
| SOCS3 | NM_003955 |
| EVL | NM_016337 |
| CDC42EP4 | NM_012121 |
| Development | |
| ID-2 | NM_002166 |
| Myb | NM_005375 |
| PAX5 | NM_016734 |
| PAX6 | NM_000280 |
| ALX4 | NM_021926 |
| Eed | NM_003797 |
| RUNX1a | NM_001754 |
| Runx2c | NM_004348 |
| SOX2 | NM_003106 |
| EBF | NM_024007 |
| Oct-4 | NM_203289 |
| NAV2 | NM_145117 |
| OVOL1 | NM_004561 |
| RARa | NM_000964 |
| RXRb | NM_021976 |
| C5orf13 | NM_004772 |
| GABPa | NM_002040 |
| POU2F3 | NM_014352 |
| ENO2 | NM_001975 |
| Rae-28 | NM_004426 |
| KIAA1199 | NM_018689 |
| GOLGA6 | NM_001038640 |
| FOG1 | NM_153813 |
| PSG1 | NM_006905 |
| Cell cycle | |
| E2F3 | NM_001949 |
| Ets2 | NM_005239 |
| c-Myc | NM_002467 |
| ARID3B | NM_006465 |
| SNF1LK | NM_173354 |
| Tumor suppressor | |
| S100A2 | NM_005978 |
| P53 | NM_000546 |
| DKK3 | NM_001018057 |
| PML | NM_033246 |
| Cell-cell signaling | |
| Notch2 | NM_024408 |
| Notch1 | NM_017617 |
| Cell adhesion | |
| CLDN16 | NM_006580 |
| COL19A1 | NM_001858 |
| EMID1 | NM_133455 |
| CDH4 | NM_001794 |
| CD99 | NM_002414 |
| Protein modification | |
| FBXO33 | NM_203301 |
| UBL7 | NM_032907 |
| LCN7 | NM_022164 |
| CLK3 | NM_003992 |
| PPIL2 | NM_148175 |
| STK32C | NM_173575 |
| RNA processing | |
| ADARB2 | NM_018702 |
| C6orf151 | NM_152551 |
| APOBEC3B | NM_004900 |
| Calcium channel | |
| CACNA1C | NM_000719 |
| Metabolism | |
| GCK | NM_000162 |
| CYP3A7 | NM_000765 |
| ACSBG1 | NM_015162 |
| Muscle contraction | |
| MYOM2 | NM_003970 |
| Histones | |
| HST4H4 | NM_175054 |
| Unknown | |
| PALM2-AKAP2 | NM_007203 |
| CCDC33 | NM_182791 |
| NOD27 | NM_032206 |
| FLJ32499 | NM_144607 |
| FLJ34306 | NM_199340 |
| FLJ39713 | AK097032 |
| INTS3 | NM_023015 |
| FLJ45537 | NM_001001709 |
| LOC388135 | NM_001039614 |
| ISLR2 | NM_020851 |
| ISLR | NM_005545 |
| miRNA | |
| hsa-mir-135b | MI0000645 |
| hsa-mir-143 | MI0000459 |
| hsa-mir-145 | MI0000461 |
| hsa-mir-337 | MI0000806 |
| hsa-mir-299 | MI0000744 |
| hsa-mir-21 | MI0000077 |
| hsa-mir-150 | MI0000479 |
| hsa-mir-220 | MI0000297 |
a
Accession numbers for protein-coding genes are from GenBank (http://www.ncbi.nlm.nih.gov/) and for miRNA genes from miRBase (http://microrna.sanger.ac.uk/sequences/index.shtml).