Table 3.

Survival and mutant frequency of E. coli strains plated in the presence of CIN

		Survival		Mutant yield		Mutant frequencyd
Strain	Dosea (μmol/plate)	Colony countb	%c	Colony countb	%c	MF	%c (95% CI)e	% Reduction (〈% increase〉)
NR 9102 (wt)	0–5	258.73	100	337.61	100	130.49	100
	10	241.29	93	219.55	65	90.99	70 (59, 82)	30
NR11634 (uvrB)	0–10	226.56	100	486.00	100	214.51	100
	20	178.54	79	15.69	3	8.79	4 (2, 6)	96
NR11475 (recA430)	0–5	305.24	100	668.28	100	218.93	100
	10	292.94	96	372.19	56	127.05	58 (41, 82)	42
NR11317 (recA56)	0–5	170.00	100	117.54	100	69.14	100
	10	105.28	62f	117.64	100	111.75	162 (117, 223)	〈62〉
NR9319 (mutL)	0–5	580.51	100	5451.25	100	939.87	100
	10	551.86	95	3319.60	61	601.53	64 (41, 100)	36

^aControl range (average of all lower doses) and highest nontoxic dose.

^bGeometric mean colony count estimated from fitted Poisson mixed model.

^cPercent of control value.

^dMutants/10⁸ survivors.

^e95% confidence intervals for mutant frequency values.

^fAt 10 μmol/plate, CIN was toxic in this strain.