Table 2.
mRNAs more abundant in txnrd1−/− than in txnrd1+/+ embryos at E7.5.
| mRNA1 | difference2 | −/− signal3 | P-value4 | description | GenBank |
|---|---|---|---|---|---|
| Igfbp1 | 11.7 | 567 | 0.04 | IGF-binding protein 1 | NM_008341 |
| Npn3 (Srxn1) | 10.9 | 474 | 0.00 | Neoplastic progression 3 (sulfiredoxin 1) | BM210600 |
| Gstμ3 | 8.7 | 338 | 0.01 | glutathione S-transferase μ3 | J03953 |
| Mash2 | 8.5 | 3061 | 0.03 | Mash-2, achaete-scute homologue-like 2 | AK010738 |
| Mash2 | 7.2 | 2267 | 0.04 | Mash-2, achaete-scute homologue-like 2 | AK010738 |
| Gstμ1 | 6.9 | 752 | 0.00 | glutathione S-transferase μ1 | NM_010358 |
| Gstμ1 | 6.5 | 1511 | 0.00 | glutathione S-transferase μ1 | NM_010358 |
| Nxf7 | 6.4 | 240 | 0.01 | nuclear RNA export factor 7 | AJ305317 |
| Gstμ1 | 5.4 | 292 | 0.01 | glutathione S-transferase μ1 | J03952 |
| Mt1 | 4.9 | 4410 | 0.01 | metallothionine 1 | NM_013602 |
| Cbr3 | 4.9 | 315 | 0.01 | carbonyl reductase 3 | AK003232 |
| Gclm | 4.4 | 1396 | 0.01 | glutamate-cysteine ligase | NM_008129 |
| Mt2 | 4.3 | 7407 | 0.02 | metallothionine 2 | AA796766 |
| Ltb4dh | 4.3 | 2330 | 0.00 | leukotriene B4 12-dehydrogenase | BC014865 |
| Mgst2 | 3.6 | 233 | 0.01 | microsomal glutathione S-transferase 2 | AV066880 |
| S100A11 | 3.6 | 1144 | 0.02 | S100 calcium-binding protein A11 | BC021916 |
| Ugt1a2 | 3.5 | 926 | 0.02 | UDP glycosyltransferase 1 A6 | D87867 |
| Ugt1a2 | 3.5 | 663 | 0.01 | UDP glycosyltransferase 1 A6 | BC019434 |
| Blvrb | 3.5 | 360 | 0.00 | biliverdin reductase B | BC027279 |
| S100A1 | 3.4 | 1144 | 0.02 | S100 calcium-binding protein A1 | AI266795 |
| Grina | 3.4 | 445 | 0.01 | glutamate receptor-associated 1 | AW212189 |
| Gaa | 3.4 | 760 | 0.01 | glucosidase, alpha, acid | BB357227 |
| Mod1 | 3.3 | 569 | 0.00 | malic enzyme, supernatent | BC011081 |
| Gaa | 3.2 | 533 | 0.00 | glucosidase, alpha, acid | NM_008064 |
| Mod1 | 3.2 | 366 | 0.03 | malic enzyme, supernatent | AK006387 |
| Htatip2 | 3.1 | 636 | 0.05 | HIV-1 tat interactive protein 2 | AF061972 |
| Cln6 | 3.1 | 391 | 0.00 | ceroid-lipofuscinosis, neuronal 6 | BB514333 |
mRNAs having multiple entries were represented by more than one oligonucleotide probe set on the arrays and thus provided independent data readouts. In some cases, probe sets were designed from different GenBank files; in other cases they were designed to a common GenBank file, as indicated in right column.
Only mRNAs having an average abundance difference of three-fold or greater between txnrd1−/− and txnrd1+/+ embryos were included.
Average signal from all three replicates given; only mRNAs in which the higher signal was ≥ 200 units were included.
All data based on statistical analysis of individual arrays from three wild-type and mutant littermate pairs using GeneSpring; only mRNAs showing sufficient signal reproducibility between the three paired array sets to yield a P-value ≤ 0.05 were included.