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. Author manuscript; available in PMC: 2007 Dec 1.
Published in final edited form as: Pharmacogenomics J. 2007 Jan 2;7(6):368–379. doi: 10.1038/sj.tpj.6500430

Table 3.

Genotype-based and allele-based association with antisocial alcohol dependencea.

SNP Phenotype Genotypes Allele
1 11 12 22 Chi Sq p-value A1 A2 Chi Sq p-value
control 206 64 12 7.224 0.027 476 88 5.3884 0.0203
73.05 22.7 2.39 0.844 0.156
AlcDep 137 73 11 347 95
61.99 33.03 4.98 0.785 0.215
2
control 272 9 0 0.694 0.405 553 9 0.3492 0.5546
96.8 3.2 0 0.984 0.016
AlcDep 205 10 0 420 10
95.35 4.65 0 0.977 0.023
3 control 23 109 129 6.912 0.0316 155 367 6.0634 0.0138
8.81 41.76 49.23 0.297 0.703
AlcDep 26 102 77 154 256
12.68 49.76 37.56 0.376 0.624
4 control 12 61 203 10.272 0.0059 85 467 5.4735 0.0193
4.35 22.10 73.55 0.154 0.846
AlcDep 8 74 128 90 330
3.81 35.24 60.95 0.214 0.786
5 control 25 114 134 9.059 0.0108 164 382 8.2322 0.0041
9.16 41.76 49.08 0.300 0.700
AlcDep 30 107 77 167 261
14.02 50.00 35.98 0.390 0.610
6 control 20 110 158 7.058 0.0293 150 426 5.2354 0.0221
6.94 38.19 54.86 0.260 0.740
AlcDep 19 107 95 145 297
8.60 48.42 42.99 0.328 0.672
7 control 128 121 24 7.937 0.0189 377 169 5.6543 0.0174
46.89 44.32 8.79 0.690 0.310
AlcDep 74 118 24 266 166
34.26 56.63 11.11 0.616 0.384
8 control 276 10 1 1.12 0.5713 562 12 0.0009 0.9754
96.17 3.48 0.35 0.979 0.021
AlcDep 211 10 0 432 10
95.48 4.52 0 0.977 0.023
9 control 271 10 0 0.35 0.5542 552 10 0.1279 0.7206
96.44 3.56 0 0.982 0.018
AlcDep 207 10 0 424 10
95.39 4.61 0 0.977 0.023
10 control 274 10 0 0.341 0.5591 558 10 0.1229 0.7259
96.48 3.52 0 0.982 0.018
AlcDep 210 10 0 430 10
95.45 4.55 0 0.977 0.023
11 control 44 130 108 8.607 0.0135 218 346 6.0673 0.0138
15.60 46.10 38.3 0.387 0.613
AlcDep 42 121 57 205 235
19.09 55.00 25.91 0.466 0.534
12 control 0 12 275 0.193 0.6606 12 562 0.0489 0.825
0.00 4.18 95.82 0.021 0.979
AlcDep 0 11 209 11 429
0.00 5.00 95 0.025 0.975
13 control 40 117 115 8.055 0.0178 197 347 4.1445 0.0418
14.71 43.01 42.28 0.362 0.638
AlcDep 34 117 65 185 247
15.74 54.17 30.09 0.428 0.572
14 control 160 95 23 6.603 0.0368 415 141 3.8463 0.0499
57.55 34.17 8.27 0.746 0.254
AlcDep 101 98 19 300 136
46.33 44.95 8.72 0.688 0.312
15 control 25 94 166 6.661 0.0358 144 426 2.83 0.0925
8.77 32.98 58.25 0.253 0.747
AlcDep 18 97 105 133 307
8.18 44.09 47.73 0.302 0.698
16 control 164 88 24 8.382 0.0151 416 136 3.6417 0.0563
59.42 31.88 8.7 0.754 0.246
AlcDep 100 94 17 294 128
47.39 44.55 8.06 0.697 0.303
17 control 172 82 15 4.3 0.1165 426 112 2.4082 0.1207
63.94 30.48 5.58 0.792 0.208
AlcDep 119 85 12 323 109
55.09 39.35 5.56 0.748 0.252
18 control 270 12 0 0.185 0.6673 552 12 0.0449 0.8322
95.74 4.26 0 0.979 0.021
AlcDep 206 11 0 423 11
94.93 5.07 0 0.975 0.025
20 control 2 36 245 0.912 0.6339 40 526 0.0024 0.9613
0.71 12.72 86.57 0.071 0.929
AlcDep 3 24 194 30 412
1.36 10.86 87.78 0.068 0.932
21 control 179 92 13 2.532 0.282 450 118 2.1369 0.1438
63.03 32.39 4.58 0.792 0.208
AlcDep 124 75 16 323 107
57.67 34.88 7.44 0.751 0.249
22 control 173 94 14 2.387 0.3032 440 122 62.0269 0.200
61.57 33.45 4.98 0.783 0.217
AlcDep 120 80 16 320 112
55.56 37.04 7.41 0.741 0.259
23 control 15 93 163 2.386 0.3033 123 419 2.1467 0.1429
5.54 34.32 60.15 0.227 0.773
AlcDep 18 80 117 116 314
8.37 37.21 54.42 0.270 0.730
24 control 72 134 81 2.587 0.2744 278 296 0.1893 0.6635
25.09 46.69 28.22 0.484 0.516
AlcDep 45 119 59 209 237
20.18 56.36 26.46 0.469 0.531
25 control 77 135 72 2.217 0.3301 289 279 0.5435 0.461
27.11 47.54 25.35 0.509 0.491
AlcDep 59 116 44 234 204
26.94 52.97 20.09 0.534 0.466
26 control 59 135 78 6.864 0.0323 253 291 6.4835 0.0109
21.69 49.63 28.68 0.465 0.535
AlcDep 66 100 45 232 190
31.28 47.39 21.33 0.550 0.450
27 control 3 73 211 1.165 0.5585 79 495 0.8197 0.3653
1.05 25.44 73.52 0.138 0.862
AlcDep 4 63 155 71 373
1.80 28.38 69.82 0.160 0.840
28 control 63 151 59 7.345 0.025 277 269 3.9322 0.0474
22.26 53.36 24.38 0.507 0.493
AlcDep 68 116 36 252 188
30.91 52.73 16.36 0.573 0.427
29 control 206 44 2 0.556 0.7575 456 48 0.2195 0.6395
81.75 17.46 0.79 0.905 0.095
AlcDep 165 38 3 368 44
80.10 18.45 1.46 0.893 0.107
30 control 66 142 62 11.707 0.0029 274 266 9.6288 0.0019
24.44 52.59 22.96 0.507 0.493
AlcDep 26 111 65 163 241
12.87 54.95 32.18 0.403 0.597
31 control 259 14 0 0.076 0.7823 532 14 0.0042 0.9483
94.87 5.13 0 0.974 0.026
AlcDep 208 10 0 426 10
95.41 4.59 0 0.977 0.023
33 control 270 15 0 0.756 0.3846 555 15 0.418 0.5179
94.74 5.26 0 0.974 0.026
AlcDep 212 8 0 432 8
96.36 3.64 0 0.982 0.018
34 control 180 98 5 7.187 0.0275 458 108 4.9379 0.0263
63.60 34.63 1.77 0.809 0.191
AlcDep 121 86 12 328 110
55.25 39.27 5.48 0.749 0.251
35 control 8 105 166 2.913 0.2331 121 437 2.204 0.1377
2.87 37.63 59.5 0.217 0.783
AlcDep 11 90 115 112 320
5.09 41.67 53.24 0.259 0.741
36 control 6 74 206 3.461 0.1772 86 486 0.659 0.4169
2.10 25.87 72.03 0.150 0.850
AlcDep 2 71 146 75 363
0.91 32.42 66.67 0.171 0.829
37 control 222 62 4 2.338 0.3107 506 70 0.9898 0.3198
77.08 21.53 1.39 0.878 0.122
AlcDep 159 60 2 378 64
71.95 27.15 0.9 0.855 0.145
38 control 197 65 12 1.813 0.4039 459 89 0.0997 0.7522
71.90 23.72 4.38 0.838 0.162
AlcDep 157 57 5 371 67
71.69 26.03 2.28 0.847 0.153
39 control 92 147 41 2.709 0.2581 331 229 2.1819 0.1396
32.86 52.50 14.64 0.591 0.409
AlcDep 60 112 42 232 196
28.04 52.34 19.63 0.542 0.458
40 control 41 144 98 2.761 0.2514 226 340 2.3488 0.1254
14.49 50.88 34.63 0.399 0.601
AlcDep 42 112 64 196 240
19.27 51.38 29.36 0.450 0.550
41 control 40 142 98 2.26 0.3231 222 338 1.6882 0.1938
14.29 50.71 35 0.396 0.604
AlcDep 41 107 67 189 241
19.07 49.77 31.16 0.440 0.560
42 control 41 147 93 2.01 0.366 229 333 1.085 0.2976
14.59 52.31 33.1 0.407 0.593
AlcDep 42 108 67 192 242
19.35 49.77 30.88 0.442 0.558
43 control 40 147 94 1.402 0.4961 227 335 0.7199 0.3962
14.23 52.31 33.45 0.404 0.596
AlcDep 38 105 66 181 237
18.18 50.24 31.58 0.433 0.567
a

Genotype and allele counts are shown for each phenotype group. The numbers below each count are frequencies, given as per cent. P-values <0.01 (after multiple test correction) are shown in bold font.

HHS Vulnerability Disclosure