Table 1.
Incidence of lung, Harderian gland, and uterine neoplasms in ethylene oxide-exposed B6C3F1 mice.a
| 0 ppm | 50 ppm | 100 ppm | |
|---|---|---|---|
| Lung | |||
| Male | |||
| Alveolar/bronchiolar adenoma | 5/50 (10%) | 11/50 (22%) | 11/50 (22%) |
| Alveolar/bronchiolar carcinoma | 6/50 (12%) | 10/50 (20%) | 16/50 (32%) |
| Female | |||
| Alveolar/bronchiolar adenoma | 2/49 (4%) | 4/48 (8%) | 17/49 (35%) |
| Alveolar/bronchiolar carcinoma | 0/49 (0%) | 1/48 (2%) | 7/49 (14%) |
| Harderian | |||
| Male | |||
| Papillary cystadenoma | 1/43 (2%) | 9/44 (20%) | 8/42 (19%) |
| Papillary cystadenocarcinoma | 0/43 (0%) | 0/44 (0%) | 1/42 (2%) |
| Female | |||
| Papillary cystadenoma | 1/46 (2%) | 6/46 (13%) | 8/47 (17%) |
| Papillary cystadenocarcinoma | 0/46 (0%) | 1/46 (2%) | 0/47 (0%) |
| Uterus | |||
| Female | |||
| Uterine carcinoma | 0/49 (0%) | 1/47 (2%) | 5/49 (10%) |
a
Male and female B6C3F1 mice were exposed to 0, 50 or 100 ppm ethylene oxide by inhalation for 6 hours/day, 5 days/week for 2 years.