Figure 1.

Immunoreactivities of native complement proteins C1q (A, D), C3 (B, E), and C4 (C, F) expressions were elevated in Tg-SwDI mice over wild-type. Forebrains of twelve months old Tg-SwDI and C57BL/6 mice were stained for fibrillar Aβ using thioflavin-S amyloid staining (green) and every one of the three complement proteins with specific antibodies (red). Positive complement immunoreactivity was associated with amyloid staining seen in thalamic regions (D, E, F), but not in cortical regions (A, B, C). Scale bars = 50 μm.