Table 2.

Comparison of architectural parameters between the control and turnover-suppressed groups (Mean ± SD, n=20 in each group).

	Control	Suppressed	% Diff. ^**	p-value (Mean Values) ^†	p-value (Arch.-BV/TV Relation) ^††
BV/TV	0.20 ± 0.03	0.24 ± 0.01	23.9	<0.0001^*
SMI	0.60 ± 0.32	0.21 ± 0.15	−65.2	0.0021^*	>0.26
Tb.Th (mm)	0.080 ± 0.007	0.091 ± 0.005	13.7	0.0005^*	>0.50
Tb.Sp (mm)	0.38 ± 0.03	0.36 ± 0.03	−7.4	0.04^*	>0.90
Tb.N	2.68 ± 0.26	2.86 ± 0.18	6.8	0.09	>0.67
BS/BV (mm⁻¹)	29.6 ± 3.1	25.0 ± 1.3	−15.7	0.0002^*	>0.14
CD (mm⁻³)	35.8 ± 8.6	29.0 ± 5.1	−18.9	0.04^*	_^‡
DA (Primary)	1.33 ± 0.08	1.32 ± 0.05	−0.5	0.82	_^‡
DA (Secondary)	1.11 ± 0.06	1.08 ± 0.05	−2.2	0.29	_^‡
DA (Tertiary)	1.20 ± 0.06	1.22 ± 0.04	1.7	0.29	_^‡
Tb.Th.SD (mm)	0.024 ± 0.003	0.026 ± 0.002	7.3	0.11	_^‡
Tb.Sp.SD (mm)	0.114 ± 0.007	0.108 ± 0.011	−5.4	0.13	>0.06
Tb.(1/N).SD	0.131 ± 0.006	0.124 ± 0.012	−6.0	0.07	>0.12

p<0.05 indicates statistically significant difference between the control and suppressed groups after accounting for replicate samples from each vertebral body.

^**

Percent difference calculated with respect to the control means.

^†

p-value for testing statistical change in mean values due to suppressed bone turnover

^††

p-value for testing statistical difference in the microarchitecture-volume fraction relation (i.e. slope and intercept) for parameters that have a significant correlation with volume fraction. Lower p-value among the p-values for the slope and intercept differences is reported.

^‡

The microarchitectural parameter did not have a statistically significant correlation with bone volume fraction.