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. Author manuscript; available in PMC: 2008 Jan 15.
Published in final edited form as: Circ Res. 2006 Mar 23;98(8):1081–1088. doi: 10.1161/01.RES.0000218493.09370.8e

Figure 5.

Figure 5

PDE regulation of cAMP signals from Glu-R and PGE1-R. A and C, Time course of ICNG in ARVMs expressing C460W/E583M CNGA2. B and D, Summary of the results obtained in a series of experiments as in A and C, respectively. A and B, Cil (1 μmol/L) exerted a transient potentiation of ICNG previously enhanced by glucagon (Glu, 1 μmol/L), while Ro (10 μmol/L) exerted a major and sustained cAMP accumulation. C and D, The cAMP response to PGE1 was revealed at the membrane by simultaneous blockade of PDE3 and PDE4 and further increased by application of IBMX. Statistically significant differences are indicated as *, p<0.05.