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. Author manuscript; available in PMC: 2008 Nov 1.
Published in final edited form as: J Mol Cell Cardiol. 2007 Aug 10;43(5):636–647. doi: 10.1016/j.yjmcc.2007.07.062

Fig. 5. Analysis of the rate of change in Vm for AP recordings.

Fig. 5

A. Details of an averaged trace of the first AP (150 ms CL), top panel; and the corresponding dVm/dt, bottom panel. The arrow indicates the starting point of the stimulation pulse. Vertical solid line indicates the maximal depolarizing rate and dotted line indicates the maximal repolarizing rate. Scale bars: 1.5 ms and 20 mV/ms.

B. Maximum upstroke rate for the first action potential in each train for CL150 recorded from Scn1b wildtype (WT, black) or Scn1b null (Null, gray) myocytes. Analysis of the data using two-way ANOVA shows a significant (p=0.0021) decrease for Scn1b null myocytes.

C. Maximum repolarization rate recorded from Scn1b wildtype (WT, black) or Scn1b null (Null, gray) myocytes for CL150 (circles) or CL300 (squares). *p < 0.05 or #p < 0.10 for Scn1b wildtype vs. Scn1b null mice.