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The fraction of amino acid mutations fixed by positive selection (α) versus their selective advantage s for αs = 6 × 10−6 (solid line). (Arrow) Maximum likelihood estimate of α using the approach of Bierne and Eyre-Walker (2004) (see Supplemental materials 6), (shaded area) 95% CI for the estimate of α, (vertical dotted line) minimum possible selection coefficent (α = 1; s = 6 × 10−6).
