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CHD1 overexpression is toxic in an spt16 mutant. Strains DY150 (wild type), DY8117 (spt16), and DY8799 (spt16 set2) were transformed with either YEp-CHD1 or the empty YEp-URA3 vector and plated on complete medium at 25°C for 3 days or on medium lacking uracil at 30°C for 2 days.
