. Author manuscript; available in PMC: 2008 Nov 1.

Published in final edited form as: J Inorg Biochem. 2007 Jul 21;101(11-12):1657–1666. doi: 10.1016/j.jinorgbio.2007.07.014

Table 1.

CODHs in nature

Type of CODH	Reactions catalyzed	Metal Centers
Aerobic or Mo-CODH
Oligotropha carboxidovorans	CO oxidation	Mo-Pterin Cu 2 [2Fe-2S] FAD
Anaerobic or Ni-CODH
Monofunctional CODH		C-Cluster, [NiFe₄-S₅]
Rhodospirillum rubrum	CO oxidation	B-Cluster, [4Fe-4S]
C. hydrogenoformans		D-Cluster, bridged [4Fe-4S]
Bifunctional CODH/ACS
Acetogenic (M. thermoacetica)	CO₂ reduction & Acetyl-CoA synthesis	B, C, D (like R. rubrum)
Methanogenic (M. thermophila)	Acetyl-CoA → CO₂+CH₄	NiNi-[4Fe-4S]_A