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. Author manuscript; available in PMC: 2008 Sep 10.
Published in final edited form as: Toxicol Lett. 2007 Jun 28;173(2):88–100. doi: 10.1016/j.toxlet.2007.06.013

Fig. 6.

Fig. 6

Effects of U0126 and catalase on the MnCl2-stimulated ERK activation in HAPI cells. Cells were pretreated for 15 min with vehicle control (V, 0.05% DMSO), indicated concentrations of U0126 (U; A), or catalase (Cat; B) prior to treatment for 3 hr with 10 µM MnCl2. The representative Western blots of phospho-ERK (p-ERK) and corresponding total ERK (ERK) in the top panel were from one experiment. The bar graphs in the bottom panel were intensities of the phospho-ERK bands expressed as a percentage of that of the MnCl2-stimulated cells and are mean ± SEM from three experiments. **, p < 0.005 compared to the medium- or vehicle-treated control cells; +, p < 0.05; ++, p < 0.005 compared to the MnCl2-treated cells.