Table 2.

Scope of Dimethylsulfoximine Desymmetrisation Reaction Using Lithium Amide 5^a

Entry	Electrophile	Product	Yield (%)	ee (%)b
1	TMSCl	2b	58	61
2	Ph2CO	2c	86	70
3	Ph2C = NTs	2d	30	28
4	PhSSPh	2e	6	62
5	CH2 = CHCH2I	2f	34	-c
6	2-BrC6H4CH2Br	2g	70	57

^a Reactions were performed using sulfoximine 1b and an excess of lithium amide 5 at -105°C in THF see Supporting Information File 1 for experimental details ^b Determined by HPLC using a chiral column. ^c Not determined