Table 1.

Classification of proteins and their functional importance in the hippocampal CA1 neuronal signal transduction network

The functional importance with respect to mutant phenotypes
	No feedback loop			Feedback loop			Total
	N	U	R	N	U	R	N	U	R
Low connectivity	49	142	34.5%	9	24	37.5%	58	166	34.9
High connectivity	19	55	34.5%	60	118	50.8%	79	173	45.7%
Total	68	197	34.5%	69	142	48.6%	137	339	40.4%
The functional importance with respect to evolutionary rates
	No feedback loop			Feedback loop			Total
	N	U	R	N	U	R	N	U	R
Low connectivity	36	208	17.3%	6	40	15.0%	42	248	16.9%
High connectivity	10	71	14.1%	37	136	27.2%	47	207	22.7%
Total	46	279	16.5%	43	176	24.4%	89	455	19.6%

U : The number of proteins belonging to the corresponding class.

N : The number of important proteins with either a "Lethal" phenotype or a "Slow" evolutionary rate.

R : N/U × 100(%).