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Mechanisms of Antibiotic Resistance Found in Acinetobacter Species
| Mechanism of Action | Antibiotic |
|---|---|
| Beta-lactamases (AmpC cephalosporinase) | Ceftazidime and extended spectrum cephalosporins |
| DNA topoisomerase mutations | Quinolones |
| Aminoglycoside-modifying enzyme | Aminoglycosides |
| Efflux pumps | Aminoglycosides, quinolones, tetracyclines, trimethoprim |
| Mobile genetic elements | Contains genes with resistance to multiple classes |
| Outer membrane protein changes | Imipenem |
