Figure 4. Isotherms for ATP-Mediated Phosphorolytic Excision of AZT-MP by WT, 3AZT, N348I, and 3AZT + N348I.

HIV-1 RT on DNA/DNA T/P (A) and RNA/DNA T/P (B). Data are the mean of three or four independent experiments. Autoradiogram of RNase H products generated during ATP-mediated excision assays on the RNA/DNA T/P (C). Experiments were carried out as described in Methods.