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Activation Segment of ASK1
(A) Interaction between the helix αC and the DFG motif. Hydrogen bonds are shown as dotted lines.
(B) Hydrogen bond network stabilizing N- and C-terminal portion of the activation segment and link the ASK1 activation segment to the catalytic loop residue Arg802.
(C) Interaction stabilizing the activation segment in the active and phosphorylated kinase PAK4 (Eswaran et al., 2007).
