Fig. 1.

Skeletal architecture at E18 of dd/ff and WT mice. (A) Images of pups after removal of the skin over the thorax. In dd/ff fetuses, the gaunt outline of the limb is striking because of the absence of the bulk of the leg musculature, and the characteristic appearance of the lung lobes is visible because of the absence of ribs; scale bar = 2 mm. (B) Whole mount preparation of forelimbs for skeletal morphometry; scale bar = 1 mm. (C) µCT 3D reconstruction of the skeletal architecture of wild type (WT) and mutant (dd/ff) mice.