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Proposed mediator cycle. RNA polymerase II (Pol II), associated with mediator and general initiation factors (TFII’s), interacts with DNA (thick horizontal line) at the start site of transcription (arrow above line). TFIIH phosphorylates the CTD (wavy line), concomitant with mediator release and the initiation of transcription. Dephosphorylation of the CTD and rebinding of mediator complete the cycle. NTP’s, nucleoside triphosphates.
