Table 2.
Effect of long-term ethanol consumption on cholesterol efflux function in rats
HDL source | Cholesterol efflux (n = 8)
|
Statistics
|
|
---|---|---|---|
(% ± SD) | P (Tukey test) | % Change in alcohol group | |
Control | 15 ± 2 | ||
Ethanol | 12 ± 3 | < .05 | −20.0 |
High-density lipoproteins were obtained by precipitation from plasma of rats fed a control or an ethanol (36% EDC) liquid diet for 8 weeks and tested for cholesterol efflux with macrophages, as described in the Methods section. Percentage of efflux was calculated as the proportion of [3H]cholesteryl oleate loaded in the macrophages that was released in the medium after a 24-hour incubation with FCS-free medium containing HDL.