Figure 3. Inhibition of activation of IL-6.

(A) Inhibition of IL-6 activation by rPIV5VΔC by co-infection with PIV5. HeLa cells were infected with mock, PIV5, rPIV5VΔC or various ratios of PIV5 to rPIV5VΔC. The levels of IL-6 mRNA were measured as in Fig. 2A. MOIs used in the experiment are indicated below the graph. (B) Inhibition of IL-6 activation by rPIV5VΔC by V. HeLa cells were transfected with p1168hIL6-F-Luc, phTK-RL and a plasmid encoding V or GFP as and then infected with viruses as in Fig. 2C. The luciferase activities were measured as described before (Fig. 2C). MK, mock infection. Error bars are standard deviation of mean (SEM).