Table 2.
Clinical Characteristics: Association with Hormonal Status
| Contraception Used |
Post-Hoc Comparisons** |
||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Combo (N=232) | Progestin (N=58) | Non-Hormone (N=948) | Combo vs. Progesterone | Combo vs. Non-Hormone | Progestin vs. Non-Hormone | ||||||||
| Characteristics | n | Mean | SD | n | Mean | SD | n | Mean | SD | p-value | |||
| Age at onset of 1st MDE | 232 | 17.22 | 6.92 | 57 | 18.65 | 7.02 | 933 | 18.96 | 7.94 | 0.0405 | |||
| Age at onset of 1st MDE, Adjusted | 18.10 | 19.36 | 18.68 | 0.4214 | |||||||||
| Number of MDE Episodes | 201 | 3.37 | 3.66 | 51 | 5.78 | 8.55 | 828 | 4.74 | 8.65 | 0.2575 | |||
| Number of MDE Episodes, Adjusted | 3.53 | 5.79 | 4.71 | 0.1013 | |||||||||
| Length of Episode (Months) | 231 | 14.64 | 29.10 | 58 | 18.54 | 38.63 | 937 | 19.74 | 40.40 | 0.2604 | |||
| Length of Episode (Months) , Adjusted | 17.71 | 18.62 | 19.01 | 0.9042 | |||||||||
| CIRS total score | 232 | 2.54 | 2.41 | 58 | 3.98 | 3.06 | 948 | 2.97 | 2.83 | 0.0021 | |||
| CIRS total score, Adjusted | 2.84 | 4.00 | 2.90 | 0.0099 | 0.0017 | 0.797 | 0.0036 | ||||||
| Length of Illness | 232 | 9.36 | 7.92 | 57 | 8.74 | 6.38 | 933 | 10.53 | 8.00 | 0.0469 | |||
| Length of Illness, Adjusted | 10.75 | 9.47 | 10.15 | 0.3957 | |||||||||
| HRSD17 | 217 | 19.51 | 5.90 | 50 | 19.54 | 5.99 | 864 | 20.62 | 6.49 | 0.0237 | |||
| HRSD17, Adjusted | 20.15 | 19.32 | 20.47 | 0.3929 | |||||||||
| IDS-C30 | 214 | 35.35 | 10.37 | 48 | 37.21 | 11.37 | 859 | 37.33 | 11.31 | 0.0479 | |||
| IDS-C30, Adjusted | 36.36 | 36.91 | 37.09 | 0.6978 | |||||||||
| QIDS-SR16 | 232 | 15.01 | 4.18 | 58 | 16.07 | 4.49 | 945 | 16.43 | 4.15 | <.0001 | |||
| QIDS-SR16, Adjusted | 15.11 | 15.98 | 16.40 | 0.0002 | 0.1647 | <.0001 | 0.4462 | ||||||
| SF-12 (Mental) | 218 | 23.91 | 7.66 | 53 | 27.33 | 9.23 | 850 | 24.65 | 8.17 | 0.0487 | |||
| SF-12 (Mental) , Adjusted | 24.13 | 27.27 | 24.61 | 0.0423 | 0.0047 | 0.4633 | 0.0285 | ||||||
| SF-12 (Physical) | 218 | 55.66 | 8.74 | 53 | 50.57 | 11.13 | 850 | 51.97 | 10.36 | <.0001 | |||
| SF-12 (Physical) , Adjusted | 54.45 | 50.86 | 52.25 | 0.0072 | 0.0044 | 0.0049 | 0.3539 | ||||||
| WSAS | 218 | 21.81 | 8.67 | 53 | 22.47 | 9.58 | 850 | 24.08 | 9.27 | 0.0014 | |||
| WSAS, Adjusted | 22.35 | 22.49 | 23.95 | 0.0560 | |||||||||
| QLESQ | 218 | 44.22 | 13.64 | 53 | 43.72 | 15.43 | 850 | 40.69 | 15.08 | 0.0081 | |||
| QLESQ, Adjusted | 43.11 | 43.72 | 40.96 | 0.0940 | |||||||||
| Combo (N=232) | Progestin (N=58) | Non-Hormone (N=948) | |||||||||||
| N | % | n | % | n | % | Unadjusted p-value | Adjusted OR Combo vs. Non Hormone | Adjusted OR Progestin vs. Non-Hormone | Adjusted p-value | ||||
| Family History of Depression | 148 | 64.3 | 31 | 53.5 | 544 | 58.0 | 0.1460 | 1.28 | 0.83 | 0.1920 | |||
| Attempted Suicide | 49 | 21.1 | 12 | 20.7 | 217 | 22.9 | 0.8008 | 0.99 | 0.80 | 0.8128 | |||
| Chronic Depression | 37 | 16.9 | 11 | 19.0 | 192 | 20.5 | 0.3057 | 0.88 | 0.95 | 0.8190 | |||
| Recurrent Depression | 158 | 73.5 | 663 | 75.1 | 41 | 75.9 | 0.8736 | 0.88 | 1.07 | 0.7275 | |||
| Age of Onset | 102 | 44.0 | 25 | 43.9 | 464 | 49.7 | 0.2277 | 0.90 | 0.93 | 0.7975 | |||
| Anxious Features | 90 | 41.3 | 21 | 40.4 | 420 | 48.3 | 0.1186 | 0.98 | 0.70 | 0.4896 | |||
| Atypical Features | 42 | 19.3 | 15 | 28.9 | 178 | 20.5 | |||||||
| Melancholic Features | 40 | 18.4 | 6 | 11.5 | 194 | 22.3 | 0.1049 | 0.84 | 0.45 | 0.1559 | |||
Model adjusted for age and years of schooling.
**
Post-Hoc comparisons were performed for adjusted models where p < 0.05.
MDE: Major Depressive Episode, CIRS: Cumulative Illness Rating Scale, HRSD17: 17-item Hamilton Rating Scale for Depression, IDS-C30: 30-item Inventory of Depressive Symptomatology, QIDSSR16: 16-item Quick Inventory of Depressive Symptomatology, SF-12: 12-item Short Form Health Survey, WSAS: Work and Social Adjustment Scale, Q-LES-Q: Quality of Life Enjoyment and Satisfaction Questionnaire