Table 3.
Baseline IDS-C30 (ROA): Hormonal Status
| Combo (N=232) | Progesterone (N=58) | Non-Hormone (N=948) | adj OR combo v. non-hormone | adj OR prog v. non-hormone | adj* p-value | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Absent | Present | Absent | Present | Absent | Present | ||||||||||||
| IDS-C30 (ROA) items | N | n | % | n | % | n | % | n | % | n | % | N | % | p-value | |||
| Sleep Onset Insomnia | 1140 | 71 | 32.6 | 147 | 67.4 | 18 | 34.6 | 34 | 65.4 | 251 | 28.9 | 619 | 71.1 | 0.4171 | 1.00 | 0.64 | 0.4192 |
| Mid-Nocturnal Insomnia | 1139 | 48 | 22.0 | 170 | 78.0 | 10 | 19.2 | 42 | 80.8 | 184 | 21.2 | 685 | 78.8 | 0.9018 | 1.30 | 1.33 | 0.3765 |
| Early Morning Insomnia | 1141 | 113 | 51.8 | 105 | 48.2 | 26 | 50.0 | 26 | 50.0 | 460 | 52.8 | 411 | 47.2 | 0.9034 | 1.44 | 1.13 | 0.1063 |
| Hypersomnia | 1139 | 133 | 61.3 | 84 | 38.7 | 31 | 60.8 | 20 | 39.2 | 646 | 74.2 | 225 | 25.8 | 0.0002 | 1.42 | 1.69 | 0.0387 |
| Mood-Sad | 1141 | 5 | 2.3 | 213 | 97.7 | 1 | 1.9 | 51 | 98.2 | 15 | 1.7 | 856 | 98.3 | 0.7072 | 0.51 | 1.61 | 0.5435 |
| Mood-Irritable | 1141 | 28 | 12.8 | 190 | 87.2 | 6 | 11.5 | 46 | 88.5 | 103 | 11.8 | 768 | 88.2 | 0.9128 | 1.13 | 0.88 | 0.8462 |
| Mood-Anxious | 1141 | 49 | 22.5 | 169 | 77.5 | 10 | 19.2 | 42 | 80.8 | 149 | 17.1 | 722 | 82.9 | 0.1818 | 0.73 | 0.82 | 0.2837 |
| Reactivity of Mood | 1140 | 52 | 23.9 | 166 | 76.1 | 15 | 28.9 | 37 | 71.2 | 223 | 25.6 | 647 | 74.4 | 0.7318 | 1.32 | 0.80 | 0.2831 |
| Mood Variation | 1140 | 165 | 76.0 | 52 | 24.0 | 37 | 71.1 | 15 | 28.9 | 664 | 76.2 | 207 | 23.8 | 0.7067 | 1.05 | 1.43 | 0.5455 |
| Quality of Mood | 1141 | 56 | 25.7 | 162 | 74.3 | 15 | 28.9 | 37 | 71.2 | 214 | 24.6 | 657 | 75.4 | 0.7590 | 0.92 | 0.78 | 0.7114 |
| Appetite-Decreased | 1138 | 116 | 53.2 | 102 | 46.8 | 32 | 61.5 | 20 | 38.5 | 417 | 48.0 | 451 | 52.0 | 0.0844 | 0.92 | 0.54 | 0.1377 |
| Appetite-Increased | 1138 | 166 | 76.1 | 52 | 23.9 | 32 | 61.5 | 20 | 38.5 | 666 | 76.7 | 202 | 23.3 | 0.0451 | 0.95 | 2.07 | 0.0568 |
| Weight-Decrease | 1140 | 157 | 72.0 | 61 | 28.0 | 36 | 70.6 | 15 | 29.4 | 583 | 66.9 | 288 | 33.1 | 0.3281 | 0.89 | 0.75 | 0.6086 |
| Weight-Increase | 1140 | 171 | 78.4 | 47 | 21.6 | 29 | 56.9 | 22 | 43.1 | 652 | 74.9 | 219 | 25.1 | 0.0060 | 0.84 | 2.44 | 0.0073 |
| Concentration/Decision Making | 1141 | 16 | 7.3 | 202 | 92.7 | 6 | 11.5 | 46 | 88.5 | 75 | 8.6 | 796 | 91.4 | 0.6040 | 1.23 | 0.70 | 0.6066 |
| Outlook-Self | 1139 | 29 | 13.3 | 189 | 86.7 | 8 | 15.4 | 44 | 84.6 | 114 | 13.1 | 755 | 86.9 | 0.8960 | 0.87 | 0.68 | 0.6204 |
| Outlook-Future | 1137 | 51 | 23.5 | 166 | 76.5 | 16 | 30.8 | 36 | 69.2 | 189 | 21.8 | 679 | 78.2 | 0.2974 | 0.92 | 0.56 | 0.2486 |
| Suicidal Ideation | 1141 | 126 | 57.8 | 92 | 42.2 | 33 | 63.5 | 19 | 36.5 | 466 | 53.5 | 405 | 46.5 | 0.2278 | 0.97 | 0.53 | 0.1818 |
| Involvement | 1141 | 34 | 15.6 | 184 | 84.4 | 9 | 17.3 | 43 | 82.7 | 91 | 10.5 | 780 | 89.5 | 0.0477 | 0.56 | 0.51 | 0.0403 |
| Energy/Fatigability | 1141 | 8 | 3.7 | 210 | 96.3 | 6 | 11.5 | 46 | 88.5 | 62 | 7.1 | 809 | 92.9 | 0.0665 | 2.52 | 0.93 | 0.0956 |
| Pleasure/Enjoyment | 1141 | 67 | 30.7 | 151 | 69.3 | 19 | 36.5 | 33 | 63.5 | 226 | 25.9 | 645 | 74.1 | 0.1148 | 0.94 | 0.49 | 0.1335 |
| Sexual Interest | 1141 | 68 | 31.2 | 150 | 68.8 | 12 | 23.1 | 40 | 76.9 | 287 | 32.9 | 584 | 67.1 | 0.3152 | 1.46 | 1.83 | 0.0491 |
| Psychomotor Slowing | 1141 | 90 | 41.3 | 128 | 58.7 | 21 | 40.4 | 31 | 59.6 | 330 | 37.9 | 541 | 62.1 | 0.6320 | 0.97 | 0.89 | 0.9325 |
| Psychomotor Agitation | 1140 | 87 | 39.9 | 131 | 60.1 | 22 | 42.3 | 30 | 57.7 | 313 | 36.0 | 557 | 64.0 | 0.4046 | 0.79 | 0.60 | 0.1437 |
| Somatic (pain) Complaints | 1141 | 52 | 23.9 | 166 | 76.1 | 11 | 21.2 | 41 | 78.9 | 183 | 21.0 | 688 | 79.0 | 0.6575 | 0.94 | 0.98 | 0.9558 |
| Sympathetic Arousal | 1140 | 86 | 39.5 | 132 | 60.5 | 19 | 36.5 | 33 | 63.5 | 298 | 34.3 | 572 | 65.7 | 0.3511 | 0.92 | 0.92 | 0.8706 |
| Panic/Phobic Symptoms | 1136 | 145 | 66.8 | 72 | 33.2 | 28 | 57.1 | 21 | 42.9 | 522 | 60.0 | 348 | 40.0 | 0.1531 | 0.80 | 1.09 | 0.4417 |
| Gastrointestinal | 1141 | 121 | 55.5 | 97 | 44.5 | 24 | 46.1 | 28 | 53.9 | 522 | 59.9 | 349 | 40.1 | 0.0906 | 1.61 | 2.09 | 0.0023 |
| Interpersonal Sensitivity | 1141 | 56 | 25.7 | 162 | 74.3 | 18 | 34.6 | 34 | 65.4 | 275 | 31.6 | 596 | 68.4 | 0.1959 | 1.26 | 0.89 | 0.4249 |
| Leaden Paralysis/Physical Energy | 1141 | 127 | 58.3 | 91 | 41.7 | 26 | 50.0 | 26 | 50.0 | 501 | 57.5 | 370 | 42.5 | 0.5403 | 1.18 | 1.63 | 0.2345 |
*
Models were adjusted for age, years of schooling and IDS total score at baseline. Post-Hoc comparisons were performed on adjusted models where p < 0.05 (in bold above).
**
Post-Hoc comparisons revealed that patients in the combination group were 0.34 times as likely to have weight increase relative to those in the progesterone group (p=0.0026), and patients in the progesterone group were 2.4 times as likely to have weight increase relative to those in the non-hormone group (p=0.0048). Regarding gastrointestinal symptoms, patients in the combination group were 1.6 times as likely to develop symptoms relative to the non-hormone group (p=0.0045).