Schematic diagram depicting the cellular and subcellular localization of ERs, PRs and ARs in the hippocampal CA1 region. Pyramidal cells contain nuclear labeling for AR (dark green) and a subset of GABAergic interneurons contains nuclear ERαs (dark pink). Pyramidal cells and some GABAergic interneurons contain cytosolic and plasma membrane-associated ERβs (blue). Dendritic spines, many belonging to pyramidal cells, contain ERαs, ERβs, ARs and PRs (purple). ERαs, ERβs, ARs and PRs are found in axons and axon terminals. Some ERα-containing terminals are cholinergic (acetylcholine; orange); some ERβ-containing terminals resemble monoaminergic terminals. Astrocytes (stars), mostly in the molecular layer, also contain ERαs, ERβs, ARs and PRs. (Summarized from Milner et al., 2001; 2005; Tabori et al., 2005; Towart et al., 2003; Waters et al., 2005).