Figure 3.

(A) Homology among the GITR cysteine pseudorepeats and those of the other murine members of TNF/NGFR family (the nontruncated only). After the name of the protein, the position of the pseudorepeat is reported (with respect to the other pseudorepeats of the protein and with respect to the position of the residues in the native protein giving the pseudorepeat). Amino acids identical or with similar function (R, K, H; D, E, N, Q; V, L, I, M; S, T; A, G) in more than 50% of the proteins were considered to be consensus and shaded; the identical are in boldface type. The respective cysteine positions in the repeats are also reported (see Fig. 2). (B) Homology among the cytoplasmic domains of murine and human CD27 and 4–1BB and of GITR. Charge (^∧) of the amino acid residues present in at least two chains belonging to different receptors is indicated.