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. 1997 Jun 10;94(12):6250–6254. doi: 10.1073/pnas.94.12.6250

Figure 2.

Figure 2

(A–I) Nota of flies expressing different E(spl) variants. (A) In the wild type, macrochaetes and microchaetes are distributed according to a characteristic, invariant pattern. (B) Gal4-mediated expression of wild-type E(spl) leads to suppression of development of all macrochaetes and most microchaetes. (C) Suppression of bristle development is weaker after expression of E(spl)ΔbHLH, which lacks the basic and the HLH domain. This variant essentially affects only microchaetes (compare with A). (D) Stronger suppression of bristle development is attained after expression of E(spl)HIII, which lacks helix III: two of the scutellar macrochaetes are missing. (E and F) Dominant–negative effects after expression of E(spl)D,stop. The arrows point to sockets with double shafts. Notice that supernumerary bristles may develop in adjacent positions (as in F). Dominant–negative effects and suppression of bristle development, respectively, are stronger after simultaneous Gal4-mediated expression of E(spl)D,stop (G) and E(spl)ΔbHLH (H) in the presence of an excess of lethal of scute (proneural) protein in the scutellum. (I) The effects of Gal4-mediated expression of lethal of scute in the scutellum: the number of scutellar bristles is increased from four in the wild type to nine in this case. In G, there are 16 scutellar brisitles, in H only four.