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. Author manuscript; available in PMC: 2009 Feb 1.
Published in final edited form as: Mol Immunol. 2007 Sep 21;45(3):632–652. doi: 10.1016/j.molimm.2006.02.033

Figure 1. Schematic of the conformational changes in the TCR postulated to signal restrictive and alloreactivity.

Figure 1

The parallelogram to rectangle conversion represents the conformational change from flIp or flOp to Φ driven by the [P+anti-P] interaction during restrictive recognition. The two signaling orientations, aW→iE and aE→iW are represented as are the opposite orientations that drive alloreactivity, which is anti-P independent. Detailed discussion is to be found in (Cohn, 2005c).