. Author manuscript; available in PMC: 2009 Feb 1.

Published in final edited form as: Mol Immunol. 2007 Sep 21;45(3):632–652. doi: 10.1016/j.molimm.2006.02.033

Table 2.

Categories of VαVβ pairs that undergo Positive Selection

Specificity of anti-R sites	Homozygote	Heterozygote
	VαVβ combinations prior to positive selection
R_T-R_A	450	800
R_A-R_A	1125	700
R_T-R_T	25	100
	1600	1600
	VαVβ combinations successfully selected
RI_T-RI_A	132	228
RII_T-RII_A	92	168
	224	396
	VαVβ combinations deleted during positive selection
RI_T-RI_T	9	36
RII_T-RII_T	4	16
	13	52
	VαVβ combinations that die-by-neglect
RI_T-RII_T	12	48
RI_T-RII_A	138	252
RII_T-RI_A	88	152
RI_A-RII_A	562	348
RI_A-RI_A	259	136
RII_A-RII_A	304	216
	1363	1152

The calculations are based on a haplotype expressing 3RI_T and 2RII_T. The number of allele-specific determinants per R equals 2. All V-gene segments are functional and of unique specificity and i-sites are class of R specific.

R_T = selecting or thymic-R

R_A = allogeneic R

Vα = 80 V-gene segments, 40 anti-RI, 40 anti-RII

Vβ = 20 V-gene segments, 10 anti-RI, 10 anti-RII

Total VαVβ pairs = 1600 (80Vα 20Vβ)