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Structural alignment of human and B. stearothermophilus TrpRS. The sequence of S. cerevisiae TrpRS is included in the alignment. Three major variations V1, V2 and V3 (besides the N-terminal extension) between eukaryotic and B. stearothermophilus TrpRS are highlighted. Lys195 of B. stearothermophilus TrpRS and its functional substitute Arg162 of human TrpRS are marked with triangles (green and red, respectively) under the sequences.
