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. 2007 Dec 3;117(12):4022–4033. doi: 10.1172/JCI32829

Figure 4. Blockade of D1 receptor–mediated pathways attenuates modafinil-induced effects on wakefulness and synaptic plasticity.

Figure 4

(A) Time course of locomotor activity shows that pretreatment of a selective D1 receptor antagonist SCH 23390 (SCH) attenuates modafinil effects on locomotor activity. Each point represents averaged beam breaks within a block of 5 minutes detected from all animals in each group. The first arrow indicates the injection of SCH 23390 or saline. The second arrow indicates the injection of modafinil or saline. (B) Mean beam breaks per 5 minutes of the last 30-minute session of our experiment monitored from all 3 groups. *P < 0.05; **P < 0.01. (C) The mean frequency of mEPSCs recorded in hypocretin/orexin neurons from all 3 groups. *P < 0.05, ANOVA; NS: P > 0.05. (D) Cumulative probability of the amplitude of mEPSCs recorded in hypocretin/orexin neurons from mice treated with saline (2,829 events), modafinil (3,140 events), and SCH 23390 plus modafinil (2,725 events).